Solution shows absolute loyalty to Ainz and the Forty-One Supreme Beings. After finishing her mission with Sebas, she beams with happiness and nearly hums with joy. In Sebas' opinion, it is not because she is returning home at last, but because she has completed her master's orders. She, along with several other Guardians, is prepared to kill Sebas without hesitation if he is proven to be disloyal towards her master, but in the end, it is unnecessary.
Solution has expressed her desire of replacing Miyoshi with the task of cleaning Ainz's body during his baths.
Herohero is the creator of Solution. Because of this, he commands the most respect and loyalty from Solution than all the other guild members. Her loyalty to her creator is strong enough to make her give up on her desire to replace Miyoshi as a bath assistant due to hearing that Herohero would have a problem with it if it were to happen.
Sebas is Solution's superior in which they show a superior-and-subordinate relationship. Even with this fact, she does not hesitate to report his mistake to Ainz or stand up against him.
Yuri is the vice-leader of the Pleiades and Solution's superior. Solution is seen as a bad younger sister by Yuri because of her sadistic and evil personality. Yuri is the only one who Solution can't refuse to answer.
Solution has a friendly relationship with her sister and colleague Lupusregina. They work together during the events of the demon invasion in the Kingdom as Jaldabaoth's servants.
Solution is jealous of her due to her closeness to Ainz.
They share the same feeling of jealousy toward Narberal due to her closeness to Ainz.
Solution has a friendly relationship with her sister and colleague Entoma. They share the same hobby of eating humans. They work together during the events of the demon invasion in the Kingdom as Jaldabaoth's servants. They share the same feeling of jealousy toward Narberal due to her closeness to Ainz.
Aureole Omega is the leader of the Pleiades Seven Sisters and is Solution Epsilon's superior. While Solution doesn't like humans, Aureole is an exception, mostly because she doesn't view her as a human because she is immortal. It has been shown that Solution cares about her, defending her when Ainz asks her if he should exile her from Nazarick because she is human.
The Floor Guardians
Albedo thinks Solution has a low-class hobby for sharing the same interests as Shalltear. She is disappointed when she is unable recruit Solution to her side.
She supports Shalltear's love for Ainz and they both share similar interests.
Solution agrees with Demiurge that killing Tuare is the best option to take. During the events of the demon invasion, Demiurge wants to put Solution in the reserve team, but instead places her alongside Sebas due to her superior detection abilities to find the kidnapped Tuare.
Solution works alongside Demiurge in his plan to make Momon a national hero. Solution plays the role of one of Jaldabaoth’s servants and fights against Nabe alongside Lupusregina and Entoma.
When Solution first meets Tuare, she thinks that Sebas brought her as a present for her. She doesn't like the idea of curing her, even though Sebas is the one who asks her to do it. She sees her as a useless human and thinks that Sebas is disobeying Ainz's orders by keeping her. When talking with Ainz about what to do with Tuare, she has the same opinion as Demiurge that killing Tuare is the best choice to make.
Zach was a servant who Solution hired to drive the carriage. Solution asked Sebas and Shalltear for permission to have him. When Zach led the carriage into an ambush, he was surprised and scared after seeing the members of the Death Spreading Brigade being killed by the Vampire Brides. Too scared to flee, Zach was led a little bit away by Solution, whom Zach had hoped to rape after the ambush. Unfortunately, he was ingested by the slime monster. He was slowly digested alive, his agony lasting two days.
Solution is jealous of Miyoshi because the Sapphire Slime is tasked with the duty of being Ainz's personal bathing assistant.