The organization was founded by the protagonist shortly before he became the new territorial guardian of E-Rantel. To promote research into the cause of the incidents relating to the Cracks, the protagonist put forth an initiative to form a new laboratory that would focus on studying and investigating such issues. To head the new research group, the protagonist sought the aid of Nfirea Bareare to become its director. The young pharmacist initially declined the invitation as he wanted to focus on his own research alone. Though Nfirea was enticed to accept after the protagonist assured him that he would be able to claim his revenge on the Chaos Beasts that murdered his love. Additionally, to add further incentive, the boy was given a Minor Healing Potion which he identified as the legendary "God's Blood". Sophie Noia was another member that joined the institute to further her interest and obsession of slimes. And lastly, Fluder Paradyne who the protagonist had recruited, and showed the old wizard the contents of Ashurbanipal which solidified his cooperation in return.
The institute was located in the remains of what was Zurrernorn's base in the E-Rantel's Cemetery. In the unlikely event of an accident, the cemetery was chosen to be their base as the crypt contained passages for the researchers to bring in dangerous creatures without threatening the city proper. The crypt was refurbished and developed as a three layer structure extending deep underground to three floors. Each and every one of the floors contained subjects of study on a specific nature. The first floor was reserved for research on magic items, such as chemicals that eliminated miasma contamination. The second floor dealt in research on Chaos Beasts and Contaminated Beasts. The floor also contained a few live specimens for examination. The last floor contained an imprisoned Gazef Stronoff who is chained in a cell and used as a specimen to study the effects of the contamination of the Crack in hopes that a cure can be developed.
Mass for the Dead Arc
- Main article: Mass for the Dead Arc
After the protagonist was officially designated as the new guardian of E-Rantel, he took both Surako and Soi to meet the new research laboratory that was hidden in the E-Rantel's Cemetery. There, the trio were presented with the latest breakthroughs that the team had so far managed to discover such as a new healing potion, domesticated slimes, and Chaos Beasts specimens. Fluder Paradyne who was now a member of the group also showed them his progress in studying the contaminated Gazef Stronoff. To collect more data, the three adventurers were allowed to battle the mad Warrior Captain so Fluder could determine the progress of his contamination and the effect on his body.
In addition to that, the institute began to do several investigations in the field on behalf of the Alliance. One led by Sophie Noia was assigned to the Quarry to reclaim the slimes from the Melting Pot and to determine what went wrong when the trap failed to dissolve the Chaos Beasts that fell into it. Along the way, adventurer teams like Blue Roses were also contracted to help assist the institute to establish a cordon around the Northern Cave to prevent an inflow of Chaos Beasts from escaping and threatening E-Rantel again. The quarantine even goes as far as to serve in preventing outsiders from tampering with the Crack site and also acted as a cover for the Sorcerer Kingdom. With the humans guarding a restricted area, they were none the wiser on what was actually happening inside the underground cave network where Nazarick conducted their own secret experiments.
Before heading out to the Dwarf Kingdom, the team Darkness visited the Institute to check on the researchers progress. Sadly the protagonist found that Gazef Stronoff was still feral, but Fluder and Sophie revealed that some promising developments made lead to a cure by investigating the Melting Pot. As it turned out, upon examining the contents of the dissolves slimes and matter, the amount of contaminated matter was less than anticipated leading the two magic casters to believe that somehow the progress in the pot had actually decontaminated what was melted. Soi was ordered to stay and guard the facility while the protagonist and Slimeko headed to the mountains.
While observing the research staff bicker on their results, Soi detected a presence in the secret passageway that connected the Institute to the sewers. The undercover adventurer went to investigate and found that the infiltrator to be none other than Enhela Read Gahi. Their encounter was interrupted when Soi detected an explosion above them.
The group was funded indirectly by Nazarick, providing useful supplies and valuable potions and magic items. So far, it's members were composed of powerful and genius magic casters.
- Due to the researchers' base being in a cemetery, there is still large amounts of negative energy which causes undead to spontaneous appear within the institute, specifically the second level. While this might be seen as an inconvenience, Nfirea believes that allowing the undead to appear has merits as he can pit the undead against Chaos Beasts and Contaminated Beasts which allows him to study how Chaos Beasts are injured before turning into Chaos Stones.