Like the Floor Guardians who manage the defense of the whole floor, Area Guardians guard a certain area appointed to them. These type of guardians were responsible for being in-charge of an individual area within a given floor as their domain specifically. As they are large in number and most of them are not very strong, the word "Guardian" usually refers to the Floor Guardians only.
The Undead King Arc
- Main article: The Undead King Arc
The Bloody Valkyrie Arc
- Main article: The Bloody Valkyrie Arc
During the unprecedented event of Shalltear Bloodfallen's brainwashing by an unknown foe using a World Item, forced Ainz to recall majority of Nazarick's forces. To protect the Floor Guardians from being compromised, he went to the Area Guardian of the Treasury, Pandora's Actor, to retrieve the stored World Items to equip his children.
The Lizard Man Heroes Arc
- Main article: The Lizard Man Heroes Arc
Ainz assigned a duty to the Area Guardian, Pandora's Actor to appraise the values of items his creator obtained from the outside world. Along the way, he also gave an order to the said Area Guardian over changing Nazarick's alarm network to his side.
The Men in the Kingdom Arc
- Main article: The Men in the Kingdom Arc
Kyouhukou of the Area Guardians was mentioned to be the one who disciplined Hilma. Later he was assigned to do the same to the Executive Council of Eight Fingers to make them subservient to Nazarick.
The Invaders of the Large Tomb Arc
- Main article: The Invaders of the Large Tomb Arc
Kyouhukou of the Area Guardians assisted in testing the Great Tomb of Nazarick's defense systems during an invasion by several teams of workers. In his part, he eliminated the worker group Heavy Masher.
The Pleiades Day Arc
- Main article: The Pleiades Day Arc
Yuri Alpha made a request to the Area Guardian, Aureole Omega to search for the location of CZ2I28 Delta. As a result, Aureole Omega pinpointed where Shizu is currently located at which was the 6th Floor of Nazarick. With authority granted from Ainz, the Area Guardian informs Yuri that she is given the right to take two of her own servants outside her domain.
The Ruler of Conspiracy Arc
- Main article: The Ruler of Conspiracy Arc
The Paladin of the Holy Kingdom Arc
- Main article: The Paladin of the Holy Kingdom Arc
To support the summoned Evil Lord Wrath and Erich String Orchestra in their upcoming battle with Ainz, the Area Guardian, Aureole Omega was ordered by Albedo to buff the five Greater Doppelgängers ahead of time before the match started.
Though most of the Area Guardians are weaker than the Floor Guardians, there are some strong NPCs among them. There are Area Guardians that are optimized for battle are considered to be stronger than some of the weaker Floor Guardians like Demiurge.
- Some Area Guardians are in charge of guarding the most vital area in Nazarick. Pandora's Actor guards the vault of the World Items in the Treasury and Aureole Omega guards the Guild Weapon in the Cherry Blossom Sanctuary.